Sandwich‐Structured Implants to Obstruct Multipath Energy Supply and Trigger Self‐Enhanced Hypoxia‐Initiated Chemotherapy Against Postsurgical Tumor Recurrence and Metastasis (Adv. Sci. 22/2023)

Postsurgical Tumor Therapy with In Situ Implantation article number 2300899, Yanteng Xu, Zhaohui Tang, Yu Tao, Mingqiang Li, and co-workers report an implantable sandwich-structured dual-drug depot to achieve self-enhanced postsurgical tumor treatment through starvation therapy hypoxia-induced chemotherapy that are triggered in sequence. The adjuvant combretastatin A4 phosphate tirapazamineloaded implants efficiently inhibits recurrence metastasis, showing great potential for clinical applications.